If you can tune your load to work with the different barrel harmonics you should be good to go.

I put a muzzle brake on my CTR in .260 and if anything accuracy was improved. I have only tried it on one load however but have shot a .35″ 5 shot group with it. I also suspected that I might need to re-tune my load but that was not the case. You can see photos of the brake and the group in the general discussion section in a thread called “hunter .243 recoil”. I put the brake on to increase the ability to see impacts after the shot since the recoil was already pretty mild.
OB